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PROJECT OF SYNTHESIS POMADE ANTI HOUND HEALING

Reduction international publications from my results obtained by using new method of extract DI SPME-GC /MS .LC/MS.HPLC-DAD. Headspace

Cnicus benedictus L. Roots. Antioxidant, Antibacterial, Anti-Inflammatory, . Anti-Alzheimer's Activity. Wound healing .formation

Cnicus benedictuscommonly known as blessed thistle is a wild medicinal plant belonging to the Asteraceae family. The Asteraceae family is rich in natural antioxidants and is widely used for medicinal purposes, especially in Asia Minor, Eastern Europe and the Mediterranean regions[1]. C. Benedictus L. is native to Turkey, where it is widely distributed, and it can also be found in several other Mediterranean countries, However,it has also been cultivated in variousgeographical areas extending from South Africa to South America [2]
The Greeks named to it as "Knekos" and It has a long andrich history of traditional medicinal uses;Due to its curative properties, in the middle ages, this plant was given the denominationsCarduus Benedictusand blessed thistle because of its caring effects, others mentioned that the scientific name (Cnicus Benedictus) it came in honor of saint “Benedict " [3].
It is an annual plant that grows up to 60 cm tall, with leathery leaves up to 30 cm long and 8 cm wide, with small spines on the edges. The yellow flowers are contained in a capitulum3-4 cm in diameter, surrounded by numerous spiny basal bracts [4].
It is known as a traditional indigenous medicine in numerous countries for the use of stomachic and toniceffects[5], antidepressant [6], anti-inflammatory [7],antipyretic [8], antibiotic and antiseptic properties, effective against wounds healing[9], skin diseases [10] .
Due to its high levels amount of phenolic compounds and flavonoids, Cnicus benedictus has shown excellent antioxidant activity [2].
Polyphenols, the most prevalent and abundant natural antioxidants, are highly valued due to theirgreat interest for their bioactivities, such as neuroprotective, anti-inflammatory, anti-cancer, anti-genotoxic, and antiglycative effects, all of these bioactivities are essentially related to their antioxidant properties [11].
In addition, pharmacological studies of crude extracts from this plant have reported neuroprotective and antioxidant activities (neurodegenerative diseases) [6], anti-inflammatory [2, 12], antioxidant [2], cytotoxicity [13] and anti-tumour[14]. In addition, previous phytochemical investigationsofthis plant revealed the existence of lignans[15], terpenoidsand steroids [16] and sesquiterpene lactone [17]