CRF (www.crfoundation.eu) is a research organization working at the interface between Digital Twin Technology, Process Scale-Up Engineering, and Model-Based Governance. We are interested in developing integrated research pathways that combine these domains to support the design and consolidation of resilient socio-technical systems, with application to sustainable and resilient water management in Mediterranean agriculture, addressing challenges such as efficient use of water resources, adaptive irrigation practices, and integrated water governance. Through Euro-Mediterranean testbeds and territorial living labs, we explore how advanced modelling, experimental validation and coordinated transition processes can contribute to SDGs localization, circular value-chain development, and to applying place-based approaches, supporting their effective translation into territorial practice. This work allows us to address the multiple dimensions of socio-technical system transformation, linking technological innovation with governance processes and cultural drivers of change, and fostering adaptive and interconnected territorial ecosystems. Contact: [email protected]