Mediterranean cereal production is increasingly threatened by seed-borne and soil-borne pathogens, fungal diseases, and microbial contamination, exacerbated by climate variability and growing resistance to conventional chemical treatments. This project proposes a non-invasive, chemical-free approach based on Non-Thermal Plasma (NTP) technology for integrated disease management, germination enhancement, and crop growth promotion in Mediterranean cereal systems. NTP operates simultaneously on three biological axes: (i) effective inactivation of seed-borne pathogens, fungal spores, and bacterial contaminants without chemical residues; (ii) acceleration of germination rates and improvement of germination uniformity through plasma-generated reactive oxygen and nitrogen species (RONS) that activate dormancy-breaking enzymatic pathways; and (iii) enhancement of early root development, shoot biomass, and overall plant vigor, producing stronger and more disease-resilient crop stands. A multidisciplinary Mediterranean consortium, combining expertise in plasma physics, plant pathology, seed physiology, agronomy, and precision agriculture , also will develop and validate scalable NTP-based pre-sowing protocols integrated with digital field monitoring and decision-support tools for real-time disease surveillance. Validation will be conducted across multiple Mediterranean countries and agro-climatic zones. This approach directly contributes to PRIMA’s objectives of sustainable, resilient, and resource-efficient Mediterranean farming systems, reducing dependence on synthetic agrochemicals while improving cereal crop productivity and food security across the region.